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p53 antibody (meLys370)

This anti-p53 antibody is a Mouse Monoclonal antibody detecting p53 in IHC (p). Suitable for Human, Mouse and Rat.
Catalog No. ABIN7250971

Quick Overview for p53 antibody (meLys370) (ABIN7250971)

Target

See all p53 (TP53) Antibodies
p53 (TP53) (Tumor Protein P53 (TP53))

Reactivity

  • 957
  • 276
  • 228
  • 140
  • 74
  • 72
  • 57
  • 39
  • 10
  • 9
  • 9
  • 6
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Mouse, Rat

Host

  • 671
  • 312
  • 5
  • 2
  • 2
Mouse

Clonality

  • 576
  • 415
  • 1
Monoclonal

Conjugate

  • 519
  • 51
  • 31
  • 20
  • 19
  • 17
  • 17
  • 17
  • 17
  • 17
  • 17
  • 17
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 12
  • 11
  • 11
  • 11
  • 11
  • 11
  • 11
  • 11
  • 10
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This p53 antibody is un-conjugated

Application

  • 727
  • 322
  • 287
  • 238
  • 210
  • 140
  • 129
  • 127
  • 122
  • 119
  • 80
  • 60
  • 32
  • 20
  • 17
  • 12
  • 10
  • 9
  • 8
  • 6
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

4A1
  • Binding Specificity

    • 39
    • 38
    • 38
    • 31
    • 31
    • 30
    • 26
    • 26
    • 24
    • 22
    • 21
    • 20
    • 19
    • 19
    • 18
    • 18
    • 18
    • 16
    • 14
    • 12
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    meLys370

    Characteristics

    Methylated antibody

    Purification

    Protein A purification

    Immunogen

    Synthetic Peptide

    Isotype

    IgG
  • Application Notes

    IHC 1:50-1:200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    p53 (TP53) (Tumor Protein P53 (TP53))

    Alternative Name

    P53

    Background

    The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

    UniProt

    P04637

    Pathways

    p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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