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p53 antibody (pSer15)

This anti-p53 antibody is a Rabbit Polyclonal antibody detecting p53 in WB. Suitable for Human.
Catalog No. ABIN7265294

Quick Overview for p53 antibody (pSer15) (ABIN7265294)

Target

See all p53 (TP53) Antibodies
p53 (TP53) (Tumor Protein P53 (TP53))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This p53 antibody is un-conjugated

Application

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Western Blotting (WB)
  • Binding Specificity

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    pSer15

    Characteristics

    Phosphorylated antibody

    Purification

    Affinity purification

    Immunogen

    A phospho specific peptide corresponding to residues surrounding S15 of human p53.

    Isotype

    IgG
  • Application Notes

    WB 1:500-1:2000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    p53 (TP53) (Tumor Protein P53 (TP53))

    Alternative Name

    p53

    Background

    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

    Molecular Weight

    Observed_MW: 53 kDa

    Calculated_MW: 43 kDa

    Gene ID

    7157

    UniProt

    P04637

    Pathways

    p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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