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PKC gamma antibody (pThr514)

PRKCG Reactivity: Human, Mouse ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN703285
$384.62
Plus shipping costs $45.00
100 μL
Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target See all PKC gamma (PRKCG) Antibodies
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Binding Specificity
    • 17
    • 15
    • 15
    • 14
    • 11
    • 11
    • 9
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr514
    Reactivity
    • 118
    • 106
    • 79
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 157
    • 5
    • 1
    Rabbit
    Clonality
    • 148
    • 17
    Polyclonal
    Conjugate
    • 65
    • 15
    • 14
    • 9
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This PKC gamma antibody is un-conjugated
    Application
    • 107
    • 64
    • 39
    • 38
    • 37
    • 15
    • 12
    • 11
    • 9
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Predicted Reactivity
    Rat,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human PKC gamma around the phosphorylation site of Thr514
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Alternative Name
    PKC gamma (PRKCG Products)
    Synonyms
    PRKCG antibody, PKC-gamma antibody, PKCC antibody, PKCG antibody, SCA14 antibody, PKCgamma antibody, Pkcc antibody, Prkcc antibody, PKC antibody, PKCI antibody, Prkc antibody, RATPKCI antibody, protein kinase C gamma antibody, protein kinase C, gamma antibody, protein kinase C gamma type antibody, PRKCG antibody, Prkcg antibody, LOC484316 antibody
    Background

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: PKCC, PKCG, SCA14, PKC-gamma, Protein kinase C gamma type, PRKCG

    Gene ID
    5582
    UniProt
    P05129
    Pathways
    WNT Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGF Signaling
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