Recombinant beta 2 Adrenergic Receptor antibody

Catalog No. ABIN7072670

The Mouse Monoclonal anti-beta 2 Adrenergic Receptor antibody is suitable to detect beta 2 Adrenergic Receptor in samples from Human. It has been validated for WB, ELISA, IF and IP.

Quick Overview for Recombinant beta 2 Adrenergic Receptor antibody (ABIN7072670)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 13D6

Product Details anti-beta 2 Adrenergic Receptor Antibody

Purpose: Anti-Beta 2 adrenergic receptor [13D6], Mouse IgG1, kappa

Specificity:

13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.

Application Notes original Clone: This antibody is recommended for the identification and analysis of the β2-adrenergic receptor. For instance, tt was used to immunostain vascular smooth muscle cells (VSMCs) against beta-2-adrenergic receptor to determine the fate of beta-2ARs ubiquitinated in a carvedilol responsive manner (Han et al., 2012). Furthermore, the antibody was utilized in the quantification of the surface level of β-2ARs via ELISA (Han et al., 2012).

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunizing mice with beta-2 adrenergic receptor.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

OriginalSpeciesName: Mouse

OriginalFormat: IgG1

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: Beta 2 adrenergic receptor

Background: R11E1, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, β-2 adrenergic receptor, β-2 adrenoreceptor, β-2 adrenoceptor, β2AR, β2-AR, I3D6

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation