ABCC6 antibody

Catalog No. ABIN7073149

Product Details anti-ABCC6 Antibody

Target: ABCC6 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse MRP6/ARA

Application Details

Application Notes: IHC/IF (M,R) 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ABCC6

Target: ABCC6 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6))

Alternative Name: MRP6/ARA (ABCC6 Products)

Synonyms: ABC34 antibody, ARA antibody, EST349056 antibody, GACI2 antibody, MLP1 antibody, MOAT-E antibody, MOATE antibody, MRP6 antibody, PXE antibody, PXE1 antibody, URG7 antibody, Abcc1b antibody, DCC antibody, Dyscalc1 antibody, Mrp6 antibody, dyscalc antibody, ATP binding cassette subfamily C member 6 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 6 antibody, ABCC6 antibody, Abcc6 antibody

Background: The ATP-binding cassette transporter 6 (ABCC6) gene, also named as MRP6, is a cellular transmembrane protein transporter and belongs to ATP-binding cassette (ABC) family. ABCC6 is an ATP-dependent transporter contains two ATP-binding domains. It is mainly found in the liver, the proximal tubules of the kidneys and the intestines. ABCC6 is involved in a pathway of extracellular nucleotide metabolism and the regulation of tissue calcification. Mutations of ABCC6 leads to pseudoxanthoma elasticum (PXE) which is a rare autosomal recessive disorder. Mutations of ABCC6 can also lead generalized arterial calcification of infancy-2 (GACI2). 27848-1-AP detects two isoforms of ABCC6 protein around 165 kDa and 96 kDa in SDS-PAGE.

Gene ID: 27421

NCBI Accession: NP_061265

UniProt: Q9R1S7