CDKN2C antibody

Catalog No. ABIN7073645

This Rabbit Polyclonal antibody specifically detects CDKN2C in WB. It exhibits reactivity toward Mouse and Rat.

Quick Overview for CDKN2C antibody (ABIN7073645)

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDKN2C Antibody

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse CDKN2C

Application Details

Application Notes: WB (M,R) 1: 500-1: 1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CDKN2C

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Alternative Name: p18 INK4c

Background: Cyclin-dependent kinase 4 inhibitor C is an enzyme encoded by the CDKN2C gene. The protein is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Molecular Weight: 18 kDa

Gene ID: 12580

NCBI Accession: NP_001288297

UniProt: Q60772

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases