Cytohesin 3 antibody

Catalog No. ABIN7073681

Product Details anti-Cytohesin 3 Antibody

Target: Cytohesin 3 (CYTH3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytohesin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Cytohesin 3

Application Details

Application Notes: WB (H,M,R) 1:300-1:600

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Cytohesin 3

Target: Cytohesin 3 (CYTH3)

Alternative Name: Cytohesin 3 (CYTH3 Products)

Synonyms: CYTH3 antibody, PSCD3 antibody, pscd3 antibody, MGC145373 antibody, ARNO3 antibody, GRP1 antibody, AI648983 antibody, CLM3 antibody, Grp1 antibody, Pscd3 antibody, Sec7 antibody, Sec7C antibody, cytohesin 3 antibody, Cytohesin 3 antibody, CYTH3 antibody, cyth3 antibody, Bm1_39360 antibody, Cyth3 antibody

Background: GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.

Molecular Weight: 46 kDa

Gene ID: 19159

NCBI Accession: NP_035312

UniProt: O08967