MIIP antibody

Catalog No. ABIN7074626

Product Details anti-MIIP Antibody

Target: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIIP antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse MIIP

Application Details

Application Notes: IHC/IF (H) 1:600-1:1200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for MIIP

Target: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Alternative Name: MIIP (MIIP Products)

Synonyms: IIP45 antibody, AA553001 antibody, AI853621 antibody, D4Wsu114e antibody, Iip45 antibody, migration and invasion inhibitory protein antibody, MIIP antibody, Miip antibody

Background: MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression.

Gene ID: 28010

NCBI Accession: NP_001020536

UniProt: A2A7Y5