CDKN2B antibody

Catalog No. ABIN706166

The Rabbit Polyclonal anti-CDKN2B antibody is suitable to detect CDKN2B in samples from Human. It has been validated for WB, IHC (p) and IF (p).

Quick Overview for CDKN2B antibody (ABIN706166)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CDKN2B Antibody

Purpose: CDKN2B/p15 INK4b Polyclonal Antibody

Cross-Reactivity: Chicken, Cow, Dog, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDKN2B

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Alternative Name: CDKN2B

Background:

Synonyms: CDK inhibitory protein, CDK4B Inhibitor, CDKN2B, Cyclin dependent kinase 4 inhibitor B, Cyclin Dependent Kinase Inhibitor 2B, Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4, Cyclin-dependent kinases 4 and 6 binding protein, INK4B, MTS 2, MTS2, Multiple Tumor Supressor 2, p14 CDK inhibitor, p14 INK4b, P15, p15 CDK inhibitor, p15 inhibits CDK4, p15 INK4b, P15INK4B, p15INK4B, TP 15, TP15.

Background: p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Molecular Weight: 15kDa

Gene ID: 1030

UniProt: P42772

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases