UCHL1 antibody (AA 151-223)

Catalog No. ABIN7091799

This Mouse Monoclonal antibody specifically detects UCHL1 in WB, IF, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for UCHL1 antibody (AA 151-223) (ABIN7091799)

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UCHL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: T2F5

Product Details anti-UCHL1 Antibody

Binding Specificity: AA 151-223

Purpose: UCHL1/PGP9.5 Monoclonal Antibody

Cross-Reactivity: Xenopus laevis

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Monkey

Purification: Purified by Protein G.

Immunogen: KLH conjugated synthetic peptide derived from human UCHL1/PGP9.5

Isotype: IgG1

Application Details

Application Notes: WB(WB=1:500-1000), IHC-P(IHC-P=1:20-50), IHC-F(IHC-F=1:400-800), IF(IF=1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Alternative Name: UCHL1/PGP9.5

Background:

Synonyms: Gracile axonal dystrophy, Neuron cytoplasmic protein 9.5, Park 5, Park5, Parkinson Disease 5, PGP 9.5, PGP95, Protein gene product 9.5, Ubiquitin C terminal esterase L1, Ubiquitin C terminal hydrolase (neuron specific), Ubiquitin C terminal hydrolase, Ubiquitin carboxyl terminal esterase L1, Ubiquitin carboxyl terminal hydrolase isozyme L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, Ubiquitin thiolesterase, Ubiquitin thiolesterase L1, UCH L1, UCH-L1, UCHL1, UCHL1_HUMAN.

Background: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Gene ID: 7345

UniProt: P09936

Pathways: Feeding Behaviour