CD46 antibody (AA 35-328)

Catalog No. ABIN7092945

This Rabbit Monoclonal antibody specifically detects CD46 in FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for CD46 antibody (AA 35-328) (ABIN7092945)

Target: CD46

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: DM145

Product Details anti-CD46 Antibody

Binding Specificity: AA 35-328

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human CD46(Cys35-Asp328) (ABIN6964079) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1/5000-10000,Flow Cyt 1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background: Synonyms:CD46,AHUS2,MCP,MIC10,TLX,TRA2.10
Description:The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 43.7KDa

Pathways: Regulation of Actin Filament Polymerization