AKR1C2 antibody

Catalog No. ABIN7111467

The Rabbit Polyclonal anti-AKR1C2 antibody (ABIN7111467) specifically detects AKR1C2 in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for AKR1C2 antibody (ABIN7111467)

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-AKR1C2 Antibody

Purpose: AKR1C2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Aldo-keto reductase family 1 member C2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for AKR1C2

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Alternative Name: AKR1C2

Background:

Synonyms: Aldo-keto reductase family 1 member C2|3-alpha-HSD3|Chlordecone reductase homolog HAKRD|Dihydrodiol dehydrogenase 2 (DD-2, DD2)|Dihydrodiol dehydrogenase/bile acid-binding protein (DD/BABP)|Type III 3-alpha-hydroxysteroid dehydrogenase|AKR1C2|DDH2

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 37 kDa

UniProt: P52895

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process