BAX antibody (AA 1-192)

Catalog No. ABIN7111961

The Mouse Monoclonal anti-BAX antibody has been validated for WB, IHC, ELISA and IF. It is suitable to detect BAX in samples from Human, Mouse and Rat.

Quick Overview for BAX antibody (AA 1-192) (ABIN7111961)

Target: BAX (BCL2-Associated X Protein (BAX))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 5F4

Product Details anti-BAX Antibody

Binding Specificity: AA 1-192

Purpose: BAX antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-192aa

Immunogen: BCL2-associated X protein

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:10000, IHC: 1:400-1:1000, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Alternative Name: BAX

Background:

Synonyms: Apoptosis regulator BAX|Bcl-2-like protein 4 (Bcl2-L-4)|BAX|BCL2L4

Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Molecular Weight: 21 kDa

Gene ID: 581

UniProt: Q07812

Pathways: p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response