BAX antibody (AA 1-192)

Catalog No. ABIN7111962

This anti-BAX antibody is a Rabbit Polyclonal antibody detecting BAX in WB, IHC, ELISA, FACS and IP. Suitable for Human, Mouse, Rat, Rabbit and Sheep.

Quick Overview for BAX antibody (AA 1-192) (ABIN7111962)

Target: BAX (BCL2-Associated X Protein (BAX))

Reactivity: Human, Mouse, Rat, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Product Details anti-BAX Antibody

Binding Specificity: AA 1-192

Purpose: BAX antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-192aa

Immunogen: BCL2-associated X protein

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:10000, IP: 1:1000-1:10000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Alternative Name: BAX

Background:

Synonyms: Apoptosis regulator BAX|Bcl-2-like protein 4 (Bcl2-L-4)|BAX|BCL2L4

Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

Molecular Weight: 21 kDa

Gene ID: 581

UniProt: Q07812

Pathways: p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response