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CDKN1B antibody
CDKN1B
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC, IF, IP
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CDKN1B Antibody
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Target
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CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Reactivity
All reactivities for CDKN1B antibodies
Human, Mouse, Rat
Host
All hosts for CDKN1B antibodies
Rabbit
Clonality
All clonalities for CDKN1B antibodies
Polyclonal
Conjugate
All conjugates for CDKN1B antibodies
This CDKN1B antibody is un-conjugated
Application
All applications for CDKN1B antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
Purification
Immunogen affinity purified
Purity
≥95 % as determined by SDS-PAGE
Immunogen
cyclin-dependent kinase inhibitor 1B(p27, Kip1)
Isotype
IgG
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Discover our top product CDKN1B Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:200-1:2000, IP: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:50-1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Expiry Date
12 months
Target Details for CDKN1B
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Target
CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Alternative Name
P27, KIP1 (CDKN1B Products )
Synonyms
CDKN4 antibody, KIP1 antibody, MEN1B antibody, MEN4 antibody, P27KIP1 antibody, cdkn1b antibody, sb:cb611 antibody, wu:fb63g10 antibody, wu:fb64g10 antibody, wu:fe18e03 antibody, CDKN1B antibody, Kip1 antibody, p27 antibody, FAM14D antibody, ISG12 antibody, ISG12A antibody, P27 antibody, Cdki1b antibody, AA408329 antibody, AI843786 antibody, p27Kip1 antibody, cdkn1bl antibody, cyclin dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Bb antibody, interferon alpha inducible protein 27 antibody, cyclin-dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Ba antibody, CDKN1B antibody, cdkn1bb antibody, IFI27 antibody, Cdkn1b antibody, cdkn1ba antibody
Background
Synonyms:CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27, KIP1, P27KIP1 Background:CDKN1B, also named as P27 or KIP1, is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. P27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controlling cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Downregulation of P27 has been implicated in the progression of several malignancies, including lung cancer, hepatocellular carcinoma, salivary cancer, oral squamous cell carcinomas, and gastric cancer.
Molecular Weight
27 kDa
Gene ID
1027
UniProt
P46527
Pathways
Cell Division Cycle , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Positive Regulation of Peptide Hormone Secretion , Negative Regulation of Hormone Secretion , Sensory Perception of Sound , Mitotic G1-G1/S Phases , DNA Replication , Positive Regulation of Endopeptidase Activity , Synthesis of DNA , Autophagy
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