zgc:63897 antibody, PLEKHF1 antibody, APPD antibody, LAPF antibody, PHAFIN1 antibody, ZFYVE15 antibody, 1810013P09Rik antibody, pleckstrin homology domain containing, family F (with FYVE domain) member 1 antibody, pleckstrin homology and FYVE domain containing 1 antibody, plekhf1 antibody, PLEKHF1 antibody, Plekhf1 antibody
Background
Synonyms:Apoptosis inducing protein, APPD, LAPF, Phafin 1, PHAFIN1, PLEKHF1, ZFYVE15 Background:May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane(LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization(MMP) resulting in the release of PDCD8.