PTPSIGMA antibody, AL022616 antibody, PTP antibody, PTP-NU3 antibody, PTPNU-3 antibody, PTPsigma antibody, Ptpt9 antibody, R-PTP-S antibody, RPTPsigma antibody, Larptp2 antibody, Ptprd antibody, Ptpsigma antibody, Ptpsigma. antibody, Rptpd antibody, protein tyrosine phosphatase, receptor type S antibody, protein tyrosine phosphatase, receptor type, S antibody, PTPRS antibody, Ptprs antibody
Background
Synonyms: Background:Type II a receptor protein tyrosine phosphatases (rPTPσ) are cell surface receptors important for nervous system development, function, and repair.The expression of rPTPσ has previously been reported in b-cells and other target organs for INS although the probes chosen did not permit to distinguish between the splice variants.Proteolytic processing near the transmembrane domain generates an extracellular N-terminal E-domain of 130 kDa and a C-terminal P-domain of approximately 85 kDa of rPTPσ,and the short splice variants rPTPσ 3 and 4 contain an E-domain of 95 kDa (PMID: 16552719). rPTPσ expression was observed in tissue lysates of the adult mouse sensory-motor cortex and thoracic spinal cord (T8-T10) as a 75-80 kDa immunoreactive band (PMID: 19780196).