RNLS antibody

Catalog No. ABIN7118395

Product Details anti-RNLS Antibody

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNLS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: chromosome 10 open reading frame 59

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RNLS

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Alternative Name: RENALASE (RNLS Products)

Synonyms: zgc:92286 antibody, C10orf59 antibody, RENALASE antibody, 6530404N21Rik antibody, AI452315 antibody, AW060440 antibody, RGD1309804 antibody, renalase, FAD dependent amine oxidase antibody, renalase, FAD-dependent amine oxidase antibody, RNLS antibody, rnls antibody, Rnls antibody

Background: Synonyms:C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS Background:RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.

Molecular Weight: 35 kDa

Gene ID: 55328

UniProt: Q5VYX0