RNF7 antibody

Catalog No. ABIN7118661

This anti-RNF7 antibody is a Rabbit Polyclonal antibody detecting RNF7 in ELISA, WB and IF. Suitable for Human, Mouse and Rat.

Quick Overview for RNF7 antibody (ABIN7118661)

Target: RNF7 (Ring Finger Protein 7 (RNF7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RNF7 Antibody

Purpose: RNF7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 7

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RNF7

Target: RNF7 (Ring Finger Protein 7 (RNF7))

Alternative Name: RNF7

Background:

Synonyms: RING-box protein 2 (Rbx2)|CKII beta-binding protein 1 (CKBBP1)|RING finger protein 7|Regulator of cullins 2|Sensitive to apoptosis gene protein|RNF7|RBX2|ROC2|SAG

Background: Probable component of the SCF(SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Molecular Weight: 13 kDa

Gene ID: 9616

UniProt: Q9UBF6

Pathways: Positive Regulation of Endopeptidase Activity