RUNX1T1 antibody (AA 1-300)

Catalog No. ABIN7118735

The Rabbit Polyclonal anti-RUNX1T1 antibody is suitable to detect RUNX1T1 in samples from Human and Mouse. It has been validated for WB, ELISA and IHC.

Quick Overview for RUNX1T1 antibody (AA 1-300) (ABIN7118735)

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX1T1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RUNX1T1 Antibody

Binding Specificity: AA 1-300

Purpose: RUNX1T1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-300aa

Immunogen: runt-related transcription factor 1, translocated to, 1(cyclin D-related)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RUNX1T1

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Alternative Name: RUNX1T1

Background:

Synonyms: Protein CBFA2T1|Cyclin-D-related protein|Eight twenty one protein|Protein ETO|Protein MTG8|Zinc finger MYND domain-containing protein 2|RUNX1T1|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2

Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Can repress transactivation mediated by TCF12(PubMed:16803958). Acts as a negative regulator of adipogenesis(By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal(PubMed:23812588).

Molecular Weight: 70-75 kDa

Gene ID: 862

UniProt: Q06455