SOCS6 antibody

Catalog No. ABIN7119606

The Rabbit Polyclonal anti-SOCS6 antibody (ABIN7119606) specifically detects SOCS6 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SOCS6 antibody (ABIN7119606)

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SOCS6 Antibody

Purpose: SOCS6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: suppressor of cytokine signaling 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6

Background:

Synonyms: Suppressor of cytokine signaling 6 (SOCS-6)|Cytokine-inducible SH2 protein 4 (CIS-4)|Suppressor of cytokine signaling 4 (SOCS-4)|SOCS6|CIS4|SOCS4

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins(By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Molecular Weight: 70 kDa

Gene ID: 9306

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis