USP44 antibody

Catalog No. ABIN7120522

Product Details anti-USP44 Antibody

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP44 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 44

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for USP44

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Alternative Name: USP44 (USP44 Products)

Synonyms: usp44 antibody, USP49 antibody, E430004F17Rik antibody, zgc:55661 antibody, ubiquitin specific peptidase 44 antibody, ubiquitin specific peptidase 44 L homeolog antibody, ubiquitin specific peptidase 44 S homeolog antibody, USP44 antibody, usp44.L antibody, usp44.S antibody, usp44 antibody, Usp44 antibody

Background: Synonyms:Deubiquitinating enzyme 44, DKFZp434D0127, FLJ14528, Ubiquitin thiolesterase 44, USP44 Background:Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.

Molecular Weight: 81 kDa

Gene ID: 84101

UniProt: Q9H0E7

Pathways: M Phase