TOX3 antibody (AA 251-389)

Catalog No. ABIN7126479

The Mouse Monoclonal anti-TOX3 antibody has been validated for WB, ELISA, IHC and Coat. It is suitable to detect TOX3 in samples from Human.

Quick Overview for TOX3 antibody (AA 251-389) (ABIN7126479)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOX3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Coating (Coat)

Product Details anti-TOX3 Antibody

Binding Specificity: AA 251-389

Specificity: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotype: IgG2b

Application Details

Application Notes:

Known_Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: A431 cell lysate (WB). Human breast or gastric carcinoma (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Alternative Name: TOX3

Background: TOX3, CAG trinucleotide repeat-containing gene F9 protein, CAGF9, TOX high mobility group box family member 3, Trinucleotide repeat containing 9 (TNRC9),TOX3 / TNRC9
Cellular localisation: Cytoplasmic & Nuclear

Molecular Weight: 63kDa

Gene ID: 27324, 460789

UniProt: O15405

Pathways: Chromatin Binding