PLP1 antibody (AA 272-277)

Catalog No. ABIN7126797

Product Details anti-PLP1 Antibody

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Binding Specificity: AA 272-277

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLP1 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Proteolipid protein (PLP) is the major myelin protein of the CNS and plays an important role in the formation and maintenance of myelin. PLP may play a role in the compaction and stabilization of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in PLP gene can lead to dysmyelinating diseases. Clone PLP1/4259 is used in the detection of PLP by various analysis methods.

Cross-Reactivity (Details): Human, Mouse, Rat, Tenerife Lizard and Cow.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Synthetic peptide GRGTKF that recognizes the C terminal region (aa272-277) of myelin proteolipid protein.

Isotype: IgG2a

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human brain tissue.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for PLP1

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Alternative Name: PLP1 (PLP1 Products)

Synonyms: GPM6C antibody, HLD1 antibody, MMPL antibody, PLP antibody, PLP/DM20 antibody, PMD antibody, SPG2 antibody, Plp antibody, PLP1 antibody, plp1 antibody, DKFZp459O081 antibody, DKFZp459O113 antibody, DM20 antibody, jimpy antibody, jp antibody, msd antibody, rsh antibody, plp antibody, hld1 antibody, mmpl antibody, plp1a antibody, pmd antibody, spg2 antibody, DMalpha2c antibody, wu:fc27f01 antibody, wu:fj36d03 antibody, wu:fj42d08 antibody, zgc:110499 antibody, PLP-B antibody, plp1-a antibody, plp1-b antibody, plp1b antibody, proteolipid protein 1 antibody, proteolipid protein (myelin) 1 antibody, myelin proteolipid protein antibody, proteolipid protein 1 L homeolog antibody, proteolipid protein 1a antibody, proteolipid protein 1 S homeolog antibody, PLP1 antibody, Plp1 antibody, plp1 antibody, Tsp_11640 antibody, plp antibody, plp1.L antibody, plp1a antibody, plp1.S antibody

Background: Myelin proteolipid protein, PLP, Lipophilin, PLP1, HLD1, SPG2, PMD, Major myelin proteolipid protein (MMPL), DM20,Proteolipid Protein / Myelin PLP
Cellular localisation: Membrane

Molecular Weight: 23-25kDa

Gene ID: 5354, 1787

UniProt: P60201