Recombinant ACE2 antibody (AA 705-805)

Catalog No. ABIN7126871

Product Details anti-ACE2 Antibody

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Antibody Type: Recombinant Antibody

Binding Specificity: AA 705-805

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa705-805) of human ACE2 (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human kidney, heart, testis or small intestine.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ACE2 (ACE2 Products)

Synonyms: ACE1 antibody, CD143 antibody, DCP antibody, DCP1 antibody, ICH antibody, MVCD3 antibody, ACEH antibody, 2010305L05Rik antibody, zgc:92514 antibody, angiotensin I converting enzyme antibody, angiotensin I converting enzyme 2 antibody, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antibody, ACE antibody, ACE2 antibody, Ace2 antibody, ace2 antibody

Background: ACE related carboxypeptidase, ACE2, ACEH, Angiotensin converting enzyme 2, Angiotensin converting enzyme like protein, Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2, Angiotensin-converting enzyme homolog, EC 3.4.17, DKFZP434A014, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2,ACE2 / Angiotensin I Converting Enzyme 2
Cellular localisation: Cell membrane. Secreted.

Molecular Weight: 92kDa

Gene ID: 59272, 178098

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour