Recombinant SIRT5 antibody
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- Target See all SIRT5 Antibodies
- SIRT5 (Sirtuin 5 (SIRT5))
- Antibody Type
- Recombinant Antibody
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This SIRT5 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- Affinity-chromatography
- Immunogen
- A synthesized peptide derived from human SIRT5
- Clone
- 9H12
- Isotype
- IgG
- Top Product
- Discover our top product SIRT5 Primary Antibody
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- Application Notes
- Recommended dilution: IHC:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SIRT5 (Sirtuin 5 (SIRT5))
- Alternative Name
- SIRT5 (SIRT5 Products)
- Synonyms
- SIR2L5 antibody, 0610012J09Rik antibody, 1500032M05Rik antibody, AV001953 antibody, zgc:92288 antibody, sirt5-a antibody, SIRT5 antibody, sir2l5 antibody, sirtuin 5 antibody, sirtuin 5 L homeolog antibody, SIRT5 antibody, Sirt5 antibody, sirt5 antibody, sirt5.L antibody, CC1G_00083 antibody
- Background
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Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Aliases: NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5), SIRT5, SIR2L5
- UniProt
- Q9NXA8
- Pathways
- SARS-CoV-2 Protein Interactome
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