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CYFIP2 antibody

CYFIP2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7129118
  • Target See all CYFIP2 Antibodies
    CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))
    Reactivity
    • 26
    • 17
    • 8
    Human
    Host
    • 23
    • 3
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CYFIP2 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of Human CYFIP2
    Isotype
    IgG
    Top Product
    Discover our top product CYFIP2 Primary Antibody
  • Application Notes
    ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))
    Alternative Name
    CYFIP2 (CYFIP2 Products)
    Synonyms
    CYFIP2 antibody, pir121 antibody, PIR121 antibody, zgc:194528 antibody, 1500004I01Rik antibody, 6430511D02Rik antibody, AA930218 antibody, AU022376 antibody, Pir121 antibody, mKIAA1168 antibody, cytoplasmic FMR1 interacting protein 2 antibody, CYFIP2 antibody, cyfip2 antibody, Cyfip2 antibody
    Background

    Background: CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

    Aliases: CYFIP2 antibody, KIAA1168 antibody, PIR121Cytoplasmic FMR1-interacting protein 2 antibody, p53-inducible protein 121 antibody

    UniProt
    Q96F07
    Pathways
    RTK Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
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