SRGAP3 antibody

Catalog No. ABIN7131182

Product Details anti-SRGAP3 Antibody

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human SRGAP3

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:5000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRGAP3

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Alternative Name: SRGAP3 (SRGAP3 Products)

Synonyms: AI452337 antibody, Arhgap14 antibody, D130026O08Rik antibody, Gbi antibody, MEGAP antibody, WRP antibody, mKIAA0411 antibody, RGD1563152 antibody, ARHGAP14 antibody, SRGAP2 antibody, RGD1566016 antibody, srGAP2 antibody, fnbp2 antibody, srgap2 antibody, SLIT-ROBO Rho GTPase activating protein 3 antibody, SLIT-ROBO Rho GTPase activating protein 2 antibody, SLIT-ROBO Rho GTPase activating protein 2 L homeolog antibody, Srgap3 antibody, SRGAP3 antibody, Srgap2 antibody, srgap3 antibody, srgap2.L antibody

Background:

Background: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

Aliases: ARHGAP 14 antibody, ARHGAP14 antibody, Gbi antibody, ME GAP antibody, MEGAP antibody, Mental disorder associated GAP antibody, Mental disorder-associated GAP antibody, Rho GTPase activating protein 14 antibody, Rho GTPase-activating protein 14 antibody, SLIT ROBO Rho GTPase activating protein 3 antibody, SLIT-ROBO Rho GTPase-activating protein 3 antibody, srGAP 2 antibody, srGAP 3 antibody, srGAP2 antibody, srGAP3 antibody, SRGP 2 antibody, SRGP2 antibody, SRGP3_HUMAN antibody, WAVE associated Rac GTPase activating protein antibody, WAVE-associated Rac GTPase-activating protein antibody, WRP antibody

UniProt: O43295