Nibrin antibody (pSer343)
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- Target See all Nibrin (NBN) Antibodies
- Nibrin (NBN)
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Binding Specificity
- pSer343
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Nibrin antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity
- Human
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of serine 343 (S-L-S(p)-Q-G) derived from Human p95/NBS1.
- Isotype
- IgG
- Top Product
- Discover our top product NBN Primary Antibody
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- Application Notes
- WB:1:500-1:1000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- Nibrin (NBN)
- Alternative Name
- NBN (NBN Products)
- Synonyms
- NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody
- Background
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Background: Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Hsu HL, et al (2005) Oncogene, 24(31): 4956-64.
Falck J, et al. (2005) Nature, 434(7033): 605-11.
Buscemi G, et al. (2004) Oncogene, 23(46): 7691-700.
Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A, 101(33): 12130-5.Aliases: AT V1 antibody, AT V2 antibody, ATV antibody, Cell cycle regulatory protein p95 antibody, FLJ10155 antibody, MGC87362 antibody, Nbn antibody, NBN_HUMAN antibody, NBS 1 antibody, NBS antibody, NBS1 antibody, Nibrin antibody, Nijmegen breakage syndrome 1 (nibrin) antibody, Nijmegen breakage syndrome antibody, Nijmegen breakage syndrome protein 1 antibody, p95 antibody, p95 protein of the MRE11/RAD50 complex antibody
- UniProt
- O60934
- Pathways
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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