Bcl-2 antibody (AA 31-80) (Biotin)

Catalog No. ABIN7144456

This anti-Bcl-2 antibody is a Rabbit Polyclonal antibody detecting Bcl-2 in ELISA. Suitable for Human.

Quick Overview for Bcl-2 antibody (AA 31-80) (Biotin) (ABIN7144456)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bcl-2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Bcl-2 Antibody (Biotin)

Binding Specificity: AA 31-80

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Apoptosis regulator Bcl-2 protein (31-80AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: BCL2

Background:

Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Aliases: Apoptosis regulator Bcl 2 antibody, Apoptosis regulator Bcl-2 antibody, Apoptosis regulator Bcl2 antibody, AW986256 antibody, B cell CLL/lymphoma 2 antibody, B cell leukemia/lymphoma 2 antibody, Bcl-2 antibody, Bcl2 antibody, BCL2_HUMAN antibody, C430015F12Rik antibody, D630044D05Rik antibody, D830018M01Rik antibody, Leukemia/lymphoma, B-cell, 2 antibody, Oncogene B-cell leukemia 2 antibody, PPP1R50 antibody, Protein phosphatase 1 regulatory subunit 50 antibody, Protein phosphatase 1, regulatory subunit 50 antibody

UniProt: P10415

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling