FHIT antibody (AA 2-147)

Catalog No. ABIN7145619

Product Details anti-FHIT Antibody

Target: FHIT (Fragile Histidine Triad (FHIT))

Binding Specificity: AA 2-147

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FHIT antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bis(5\\\'-adenosyl)-triphosphatase protein (2-147AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Alternative Name: FHIT (FHIT Products)

Synonyms: AP3Aase antibody, FRA3B antibody, FHIT antibody, zgc:73176 antibody, AW045638 antibody, Fra14A2 antibody, LOC100223655 antibody, fragile histidine triad antibody, fragile histidine triad gene antibody, fragile histidine triad protein antibody, fragile histidine triad L homeolog antibody, FHIT antibody, Fhit antibody, fhit antibody, PY07476 antibody, fhit.L antibody

Background:

Background: Cleaves P1-P3-bis(5\\\'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5\\\'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5\\\'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Aliases: FHITBis(5'-adenosyl)-triphosphatase antibody, EC 3.6.1.29 antibody, AP3A hydrolase antibody, AP3Aase antibody, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody, Dinucleosidetriphosphatase antibody, Fragile histidine triad protein antibody

UniProt: P49789