UIMC1 antibody (AA 161-235)

Catalog No. ABIN7145750

Product Details anti-UIMC1 Antibody

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Binding Specificity: AA 161-235

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UIMC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human BRCA1-A complex subunit RAP80 protein (161-235AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UIMC1

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Alternative Name: UIMC1 (UIMC1 Products)

Synonyms: UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody

Background:

Background: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds \\\'Lys-63\\\'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \\\'Lys-63\\\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48\\\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Aliases: BRCA1-A complex subunit RAP80 antibody, Nuclear zinc finger protein RAP80 antibody, OTTHUMP00000161441 antibody, OTTHUMP00000223372 antibody, OTTHUMP00000223374 antibody, RAP80 antibody, Receptor associated protein 80 antibody, Receptor-associated protein 80 antibody, Retinoid X receptor interacting protein 110 antibody, Retinoid x receptor interacting protein antibody, Retinoid X receptor-interacting protein 110 antibody, RIP110 antibody, Rxrip110 antibody, Ubiquitin interaction motif containing 1 antibody, Ubiquitin interaction motif containing protein 1 antibody, Ubiquitin interaction motif-containing protein 1 antibody, UIMC1 antibody, UIMC1_HUMAN antibody, X2HRIP110 antibody

UniProt: Q96RL1

Pathways: DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus