UIMC1 antibody (AA 161-235) (Biotin)

Catalog No. ABIN7145751

The Rabbit Polyclonal anti-UIMC1 antibody has been validated for ELISA. It is suitable to detect UIMC1 in samples from Human.

Quick Overview for UIMC1 antibody (AA 161-235) (Biotin) (ABIN7145751)

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UIMC1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-UIMC1 Antibody (Biotin)

Binding Specificity: AA 161-235

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human BRCA1-A complex subunit RAP80 protein (161-235AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UIMC1

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Alternative Name: UIMC1

Background:

Background: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds \'Lys-63\'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \'Lys-63\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Aliases: BRCA1-A complex subunit RAP80 antibody, Nuclear zinc finger protein RAP80 antibody, OTTHUMP00000161441 antibody, OTTHUMP00000223372 antibody, OTTHUMP00000223374 antibody, RAP80 antibody, Receptor associated protein 80 antibody, Receptor-associated protein 80 antibody, Retinoid X receptor interacting protein 110 antibody, Retinoid x receptor interacting protein antibody, Retinoid X receptor-interacting protein 110 antibody, RIP110 antibody, Rxrip110 antibody, Ubiquitin interaction motif containing 1 antibody, Ubiquitin interaction motif containing protein 1 antibody, Ubiquitin interaction motif-containing protein 1 antibody, UIMC1 antibody, UIMC1_HUMAN antibody, X2HRIP110 antibody

UniProt: Q96RL1

Pathways: DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus