ARFGEF2 antibody (AA 200-317)

Catalog No. ABIN7145776

Product Details anti-ARFGEF2 Antibody

Target: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Binding Specificity: AA 200-317

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARFGEF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 protein (200-317AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARFGEF2

Target: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Alternative Name: ARFGEF2 (ARFGEF2 Products)

Synonyms: AI463430 antibody, AW493672 antibody, BIG2 antibody, E230011G24Rik antibody, Big2 antibody, PVNH2 antibody, dJ1164I10.1 antibody, ADP ribosylation factor guanine nucleotide exchange factor 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) antibody, ARFGEF2 antibody, Arfgef2 antibody

Background:

Background: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

Aliases: ARFGEF2 antibody, ARFGEP2 antibody, BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody, Brefeldin A-inhibited GEP 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody

UniProt: Q9Y6D5