p21 antibody (AA 2-164)

Catalog No. ABIN7148907

The Rabbit Polyclonal anti-p21 antibody has been validated for IHC, ELISA and IF. It is suitable to detect p21 in samples from Human.

Quick Overview for p21 antibody (AA 2-164) (ABIN7148907)

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p21 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-p21 Antibody

Binding Specificity: AA 2-164

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase inhibitor 1 protein (2-164AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:1000-1:2000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for p21

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Alternative Name: CDKN1A

Background:

Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Aliases: CAP20 antibody, CDK-interacting protein 1 antibody, CDKI antibody, CDKN1 antibody, Cdkn1a antibody, CDN1A_HUMAN antibody, CIP1 antibody, Cyclin Dependent Kinase Inhibitor 1A antibody, Cyclin-dependent kinase inhibitor 1 antibody, Cyclin-dependent kinase inhibitor 1A (P21) antibody, Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody, DNA Synthesis Inhibitor antibody, MDA-6 antibody, MDA6 antibody, Melanoma differentiation-associated protein 6 antibody, Melanoma differentiation-associated protein antibody, p21 antibody, P21 protein antibody, p21CIP1 antibody, p21Cip1/Waf1 antibody, p21WAF antibody, PIC1 antibody, SDI1 antibody, SLC12A9 antibody, WAF1 antibody, Wild type p53 activated fragment 1 (WAF1) antibody, Wild type p53 activated fragment 1 antibody, Wildtype p53-activated fragment 1 antibody

UniProt: P38936

Pathways: p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy