DPP4 antibody (AA 473-588) (HRP)

Catalog No. ABIN7149987

The Rabbit Polyclonal anti-DPP4 antibody has been validated for ELISA. It is suitable to detect DPP4 in samples from Human.

Quick Overview for DPP4 antibody (AA 473-588) (HRP) (ABIN7149987)

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPP4 antibody is conjugated to HRP

Application: ELISA

Product Details anti-DPP4 Antibody (HRP)

Binding Specificity: AA 473-588

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dipeptidyl peptidase 4 protein (473-588AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DPP4

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Alternative Name: DPP4

Background:

Background: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Aliases: ADABP antibody, ADCP-2 antibody, ADCP2 antibody, Adenosine deaminase complexing protein 2 antibody, CD26 antibody, Dipeptidyl peptidase 4 antibody, Dipeptidyl peptidase 4 soluble form antibody, Dipeptidyl peptidase IV antibody, Dipeptidyl peptidase IV membrane form antibody, Dipeptidyl peptidase IV soluble form antibody, DPP IV antibody, DPP4 antibody, DPP4_HUMAN antibody, DPPIV antibody, T-cell activation antigen CD26 antibody, TP103 antibody

UniProt: P27487

Pathways: Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity