DNA2 antibody

Catalog No. ABIN7228258

This Rabbit Polyclonal antibody specifically detects DNA2 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for DNA2 antibody (ABIN7228258)

Target: DNA2 (DNA Replication Helicase 2 Homolog (DNA2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNA2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-DNA2 Antibody

Purpose: Rabbit Anti-DNA2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DNA2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DNA2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DNA2

Target: DNA2 (DNA Replication Helicase 2 Homolog (DNA2))

Alternative Name: DNA2

Background: DNA replication ATP-dependent helicase/nuclease DNA2, hDNA2, DNA replication ATP-dependent helicase-like homolog, DNA replication nuclease DNA2 , DNA replication ATP-dependent helicase DNA2DNA2 (DNA Replication Helicase/Nuclease 2) is a Protein Coding gene. Diseases associated with DNA2 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6 and Seckel Syndrome 8. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. DNA2 encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in DNA2 are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for DNA2.

Molecular Weight: 116kD

Gene ID: 1763

UniProt: P51530

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA