rRNA 2'-O-Methyltransferase Fibrillarin (FBL) (AA 1-64) antibody (FITC)

Catalog No. ABIN7359824

Product Details

Target: rRNA 2'-O-Methyltransferase Fibrillarin (FBL)

Binding Specificity: AA 1-64

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human H/ACA ribonucleoprotein complex subunit 3 protein (1-64AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: rRNA 2'-O-Methyltransferase Fibrillarin (FBL)

Alternative Name: NOP1

Background:

Background: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (\\\"psi\\\") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Aliases: DKCB1 antibody, H/ACA ribonucleoprotein complex subunit 3 antibody, homolog of yeast Nop10p antibody, MGC70651 antibody, NOLA3 antibody, NOP10 antibody, NOP10 ribonucleoprotein homolog (yeast) antibody, NOP10_HUMAN antibody, NOP10P antibody, Nucleolar protein 10 antibody, Nucleolar protein family A member 3 antibody, nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody, snoRNP protein NOP10 antibody

UniProt: Q9NPE3