IGHA2 antibody (AA 36-111)

Catalog No. ABIN7156081

Product Details anti-IGHA2 Antibody

Target: IGHA2 (Immunoglobulin Heavy Constant alpha 2 (A2m Marker) (IGHA2))

Binding Specificity: AA 36-111

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGHA2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Immunoglobulin heavy constant alpha 2 protein (36-111AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IGHA2

Target: IGHA2 (Immunoglobulin Heavy Constant alpha 2 (A2m Marker) (IGHA2))

Alternative Name: IGHA2 (IGHA2 Products)

Synonyms: immunoglobulin heavy constant alpha 2 (A2m marker) antibody, IGHA2 antibody

Background:

Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

Aliases: IGHA2Immunoglobulin heavy constant alpha 2 antibody, Ig alpha-2 chain C region antibody, Ig alpha-2 chain C region BUT antibody, Ig alpha-2 chain C region LAN antibody

UniProt: P01877