Integrin beta 7 antibody (AA 1-140)

Catalog No. ABIN7156498

Product Details anti-Integrin beta 7 Antibody

Target: Integrin beta 7 (ITGB7)

Binding Specificity: AA 1-140

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Integrin beta-7 protein (1-140AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: ITGB7 (ITGB7 Products)

Synonyms: Ly69 antibody, integrin beta 7 antibody, integrin subunit beta 7 antibody, integrin, beta 7 antibody, Itgb7 antibody, ITGB7 antibody

Background:

Background: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Aliases: Gut homing receptor beta subunit antibody, Integrin beta 7 subunit antibody, Integrin beta-7 antibody, Integrin beta-P antibody, Integrin, beta 7 antibody, ITB7 antibody, ITB7_HUMAN antibody, Itgb7 antibody, Ly69 antibody, M290 IEL antigen antibody

UniProt: P26010

Pathways: Integrin Complex