PRKRA antibody (AA 1-313)

Catalog No. ABIN7156699

Product Details anti-PRKRA Antibody

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Binding Specificity: AA 1-313

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKRA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PRKRA

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Alternative Name: PRKRA (PRKRA Products)

Synonyms: PRKRA antibody, AV120107 antibody, PRK antibody, Pact antibody, RAX antibody, lear antibody, DYT16 antibody, PACT antibody, im:7151758 antibody, zgc:162619 antibody, dyt16 antibody, pact antibody, prkra-a antibody, prkra-b antibody, rax antibody, rbpa antibody, protein activator of interferon induced protein kinase EIF2AK2 antibody, protein kinase, interferon inducible double stranded RNA dependent activator antibody, protein kinase, interferon-inducible double stranded RNA dependent activator antibody, protein activator of interferon induced protein kinase EIF2AK2 L homeolog antibody, PRKRA antibody, Prkra antibody, prkra antibody, prkra.L antibody

Background:

Background: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \\\'Lys-386\\\' at \\\'Ser-392\\\' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Aliases: DYT16 antibody, HSD14 antibody, Interferon inducible double stranded RNA dependent protein kinase activator A antibody, interferon-inducible double stranded RNA-dependent activator antibody, Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody, PACT antibody, PKR associated protein X antibody, PKR associating protein X antibody, PKR-associated protein X antibody, PKR-associating protein X antibody, PRKRA antibody, PRKRA_HUMAN antibody, Protein activator of the interferon induced protein kinase antibody, Protein activator of the interferon-induced protein kinase antibody, Protein kinase antibody, Protein kinase interferon inducible double stranded RNA dependent activator antibody, RAX antibody

UniProt: O75569

Pathways: Regulatory RNA Pathways