AIM2 antibody (AA 81-326) (Biotin)

Catalog No. ABIN7156704

The Rabbit Polyclonal anti-AIM2 antibody has been validated for ELISA. It is suitable to detect AIM2 in samples from Human.

Quick Overview for AIM2 antibody (AA 81-326) (Biotin) (ABIN7156704)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIM2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-AIM2 Antibody (Biotin)

Binding Specificity: AA 81-326

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Alternative Name: AIM2

Background:

Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Aliases: Absent in melanoma 2 antibody, AIM 2 antibody, Aim2 antibody, AIM2_HUMAN antibody, Interferon-inducible protein AIM2 antibody, OTTHUMP00000035296 antibody, PYHIN4 antibody

UniProt: O14862

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome