KHDRBS2 antibody (AA 1-349)

Catalog No. ABIN7157478

Product Details anti-KHDRBS2 Antibody

Target: KHDRBS2 (KH Domain Containing, RNA Binding, Signal Transduction Associated 2 (KHDRBS2))

Binding Specificity: AA 1-349

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHDRBS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein (1-349AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KHDRBS2

Target: KHDRBS2 (KH Domain Containing, RNA Binding, Signal Transduction Associated 2 (KHDRBS2))

Alternative Name: KHDRBS2 (KHDRBS2 Products)

Synonyms: slm1 antibody, slm-1 antibody, MGC145973 antibody, ba535f17.1 antibody, zgc:153588 antibody, SLM-1 antibody, SLM1 antibody, bA535F17.1 antibody, 6330586C16Rik antibody, Slim1 antibody, Slm1 antibody, KH RNA binding domain containing, signal transduction associated 2 antibody, KH domain containing, RNA binding, signal transduction associated 2 antibody, KHDRBS2 antibody, khdrbs2 antibody, Khdrbs2 antibody

Background:

Background: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Aliases: KH domain containing, RNA binding, signal transduction associated protein 2 antibody, 6330586C16Rik antibody, bA535F17.1 antibody, FLJ38664 antibody, hSLM 1 antibody, hSLM-1 antibody, KH domain containing, RNA binding, signal transduction associated 2 antibody, KH domain-containing antibody, KHDR2_HUMAN antibody, khdrbs2 antibody, MGC26664 antibody, RNA-binding antibody, Sam68 like mammalian protein 1 antibody, Sam68-like mammalian protein 1 antibody, signal transduction-associated protein 2 antibody, SLM 1 antibody, SLM-1 antibody, SLM1 antibody

UniProt: Q5VWX1