KIT antibody (AA 73-195)

Catalog No. ABIN7159029

The Rabbit Polyclonal anti-KIT antibody has been validated for ELISA and IF. It is suitable to detect KIT in samples from Human.

Quick Overview for KIT antibody (AA 73-195) (ABIN7159029)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIT antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-KIT Antibody

Binding Specificity: AA 73-195

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mast/stem cell growth factor receptor Kit protein (73-195AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Alternative Name: KIT

Background:

Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Aliases: C Kit antibody, c-Kit antibody, c-Kit Ligand antibody, CD117 antibody, Kit antibody, Kit Ligand antibody, KIT oncogene antibody, KIT proto oncogene receptor tyrosine kinase antibody, KIT_HUMAN antibody, Mast cell growth factor receptor antibody, Mast/stem cell growth factor receptor Kit antibody, MGF antibody, p145 c-kit antibody, PBT antibody, Piebald trait protein antibody, Proto oncogene c Kit antibody, Proto oncogene tyrosine protein kinase Kit antibody, Proto-oncogene c-Kit antibody, SCF Receptor antibody, SCFR antibody, soluble KIT variant 1 antibody, Steel Factor Receptor antibody, Stem cell factor receptor antibody, tyrosine protein kinase Kit antibody, Tyrosine-protein kinase Kit antibody, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog antibody, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein antibody, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog antibody

UniProt: P10721

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity