MDC1 antibody (AA 1892-2082)
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- Target See all MDC1 Antibodies
- MDC1 (Mdc1 (MDC1))
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Binding Specificity
- AA 1892-2082
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MDC1 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA)
- Isotype
- IgG
- Top Product
- Discover our top product MDC1 Primary Antibody
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anti-Mdc1 (MDC1) antibody
MDC1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Mdc1 (MDC1) (AA 1-100) antibodyMDC1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Mdc1 (MDC1) (AA 31-130) antibodyMDC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Mdc1 (MDC1) (N-Term) antibodyMDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 unconjugated
anti-Mdc1 (MDC1) (N-Term) antibody (HRP)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 HRP
anti-Mdc1 (MDC1) (N-Term) antibody (FITC)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 FITC
anti-Mdc1 (MDC1) (N-Term) antibody (Alkaline Phosphatase (AP))MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Alkaline Phosphatase (AP)
anti-Mdc1 (MDC1) (N-Term) antibody (Biotin)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Biotin
anti-Mdc1 (MDC1) (N-Term) antibody (PE)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 PE
anti-Mdc1 (MDC1) (N-Term) antibody (APC)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 APC
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- MDC1 (Mdc1 (MDC1))
- Alternative Name
- MDC1 (MDC1 Products)
- Synonyms
- 6820401C03 antibody, AA413496 antibody, Nfbd1 antibody, mKIAA0170 antibody, NFBD1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA-damage checkpoint 1 antibody, Mdc1 antibody, MDC1 antibody
- Background
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Background: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by \'Ser-139\' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
Aliases: Homologue to Drosophila photoreceptor protein calphotin antibody, MDC 1 antibody, Mdc1 antibody, MDC1_HUMAN antibody, Mediation of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint protein 1 antibody, NFBD 1 antibody, NFBD1 antibody, Nuclear factor with BRCT domains 1 antibody, Nuclear Factor with BRCT Domains Protein 1 antibody
- UniProt
- Q14676
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