CD46 antibody (AA 164-325) (Biotin)

Catalog No. ABIN7159321

This anti-CD46 antibody is a Rabbit Polyclonal antibody detecting CD46 in ELISA. Suitable for Human.

Quick Overview for CD46 antibody (AA 164-325) (Biotin) (ABIN7159321)

Target: CD46

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CD46 Antibody (Biotin)

Binding Specificity: AA 164-325

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Membrane cofactor protein (164-325AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background:

Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Aliases: AHUS2 antibody, Antigen defined by monoclonal antibody TRA 2 10 antibody, Antigen identified by monoclonal antibody TRA 2 10 antibody, CD46 antibody, CD46 antigen antibody, CD46 antigen complement regulatory protein antibody, CD46 Molecule antibody, CD46 Molecule complement regulatory protein antibody, Complement membrane cofactor protein antibody, MCP antibody, MCP_HUMAN antibody, Measles virus receptor antibody, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody, Membrane cofactor protein antibody, MGC26544 antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Trophoblast leucocyte common antigen antibody, Trophoblast leukocyte common antigen antibody, Trophoblast lymphocyte cross reactive antigen antibody

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization