ERK1 antibody (AA 11-379) (FITC)

Catalog No. ABIN7160001

The Rabbit Polyclonal anti-ERK1 antibody has been validated for . It is suitable to detect ERK1 in samples from Human.

Quick Overview for ERK1 antibody (AA 11-379) (FITC) (ABIN7160001)

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERK1 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-ERK1 Antibody (FITC)

Binding Specificity: AA 11-379

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitogen-activated protein kinase 3 protein (11-379AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERK1

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Alternative Name: MAPK3

Background:

Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Aliases: ERK 1 antibody, ERK-1 antibody, ERK1 antibody, ERT 2 antibody, ERT2 antibody, Extracellular Signal Regulated Kinase 1 antibody, Extracellular signal related kinase 1 antibody, Extracellular signal-regulated kinase 1 antibody, HGNC6877 antibody, HS44KDAP antibody, HUMKER1A antibody, Insulin Stimulated MAP2 Kinase antibody, Insulin-stimulated MAP2 kinase antibody, MAP kinase 1 antibody, MAP kinase 3 antibody, MAP Kinase antibody, MAP kinase isoform p44 antibody, MAPK 1 antibody, MAPK 3 antibody, MAPK antibody, MAPK1 antibody, Mapk3 antibody, MGC20180 antibody, Microtubule Associated Protein 2 Kinase antibody, Microtubule-associated protein 2 kinase antibody, Mitogen Activated Protein Kinase 3 antibody, Mitogen-activated protein kinase 1 antibody, Mitogen-activated protein kinase 3 antibody, MK03_HUMAN antibody, OTTHUMP00000174538 antibody, OTTHUMP00000174541 antibody, p44 ERK1 antibody, p44 MAPK antibody, p44-ERK1 antibody, p44-MAPK antibody, P44ERK1 antibody, P44MAPK antibody, PRKM 3 antibody, PRKM3 antibody, Protein Kinase Mitogen Activated 3 antibody

UniProt: P27361

Pathways: MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins