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Nischarin antibody (AA 500-700)

NISCH Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7161622
  • Target See all Nischarin (NISCH) Antibodies
    Nischarin (NISCH)
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 500-700
    Reactivity
    • 8
    • 4
    • 1
    Human
    Host
    • 7
    • 3
    Rabbit
    Clonality
    • 7
    • 3
    Polyclonal
    Conjugate
    • 10
    This Nischarin antibody is un-conjugated
    Application
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Nischarin protein (500-700AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Nischarin (NISCH)
    Alternative Name
    NISCH (NISCH Products)
    Synonyms
    NISCH antibody, IRAS antibody, 1200007D05Rik antibody, 3202002H23Rik antibody, AW494485 antibody, I-1 antibody, IR1 antibody, hIRAS antibody, nischarin antibody, nischarin S homeolog antibody, NISCH antibody, Cyan7822_6841 antibody, nisch.S antibody, nisch antibody, Nisch antibody
    Background

    Background: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 \\\'Tyr-508\\\' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

    Aliases: NISCH antibody, IRAS antibody, KIAA0975 antibody, Nischarin antibody, Imidazoline receptor 1 antibody, I-1 antibody, IR1 antibody, Imidazoline receptor antisera-selected protein antibody, hIRAS antibody, Imidazoline-1 receptor antibody, I1R antibody, Imidazoline-1 receptor candidate protein antibody, I-1 receptor candidate protein antibody, I1R candidate protein antibody

    UniProt
    Q9Y2I1
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