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NCOA1 antibody (AA 284-393) (Biotin)

This Rabbit Polyclonal antibody specifically detects NCOA1 in ELISA. It exhibits reactivity toward Human.
Catalog No. ABIN7161857

Quick Overview for NCOA1 antibody (AA 284-393) (Biotin) (ABIN7161857)

Target

See all NCOA1 Antibodies
NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivity

  • 62
  • 38
  • 18
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Host

  • 68
  • 9
Rabbit

Clonality

  • 57
  • 20
Polyclonal

Conjugate

  • 45
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  • 2
  • 2
  • 2
  • 2
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This NCOA1 antibody is conjugated to Biotin

Application

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  • 7
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ELISA
  • Binding Specificity

    • 15
    • 5
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    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
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    AA 284-393

    Cross-Reactivity

    Human

    Purification

    >95%, Protein G purified

    Immunogen

    Recombinant Human Nuclear receptor coactivator 1 protein (284-393AA)

    Isotype

    IgG
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

    Alternative Name

    NCOA1

    Background

    Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

    Aliases: bHLHe74 antibody, Class E basic helix-loop-helix protein 74 antibody, F SRC 1 antibody, Hin 2 protein antibody, Hin2 protein antibody, MGC129719 antibody, MGC129720 antibody, mNRC 1 antibody, NCoA 1 antibody, NCoA-1 antibody, Ncoa1 antibody, NCOA1_HUMAN antibody, Nuclear receptor coactivator 1 antibody, Nuclear receptor coactivator protein 1 antibody, NY REN 52 antigen antibody, Protein Hin 2 antibody, Protein Hin-2 antibody, Protein Hin2 antibody, Renal carcinoma antigen NY REN 52 antibody, Renal carcinoma antigen NY-REN-52 antibody, RIP 160 antibody, RIP160 antibody, SRC 1 antibody, SRC-1 antibody, Steroid receptor coactivator 1 antibody

    UniProt

    Q15788

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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