Presenilin 2 antibody (AA 7-77)

Catalog No. ABIN7164268

This anti-Presenilin 2 antibody is a Rabbit Polyclonal antibody detecting Presenilin 2 in WB and ELISA. Suitable for Human.

Quick Overview for Presenilin 2 antibody (AA 7-77) (ABIN7164268)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Presenilin 2 Antibody

Binding Specificity: AA 7-77

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Presenilin-2 protein (7-77AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: PSEN2

Background:

Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Aliases: AD3L antibody, AD3LP antibody, AD4 antibody, AD5 antibody, Alzheimer disease 4 antibody, CMD1V antibody, E5-1 antibody, OTTHUMP00000035671 antibody, OTTHUMP00000035672 antibody, OTTHUMP00000228286 antibody, OTTHUMP00000228288 antibody, Presenilin 2 (Alzheimer disease 4) antibody, Presenilin 2 antibody, Presenilin-2 CTF subunit antibody, PS-2 antibody, PS2 antibody, Psen2 antibody, PSN2_HUMAN antibody, PSNL2 antibody, STM-2 antibody, STM2 antibody

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway